Serotic wheels like any other wheel requires choosing winning numbers and to me choosing winning pairs is next to impossible.
That's the nub of it of course.
But I am not sure it is necessary to pick pairs of numbers as you have alluded to above. The construction process for
Serotic Wheels in Wheel Generator allows you to have groups of numbers such as 3 groups of 5 numbers - Wheel Generator will group any two numbers with any two numbers from each of the other groups (for a 6 ball draw). A full
Serotic wheel will give you the jackpot if within each of your number groups you have two of the prize winning numbers, but to do this will require a budget rather more than most of us are likely to play with. WG can give you a reduced
Serotic wheel set (which I think is unique to WG) with a guarantee ie 4 if 6 that will give a much reduced budget play. Thus the trick is to get at least two numbers in each of you number groups. (Note also you could have in WG 6 groups of 3 numbers requiring 1 number in each group to be a winning number.)
If you have some number selection technique
Serotic or matrix wheels are probably a good play, but if you don't and you just wish to play say 15 or 18 (or xx) numbers as opposed to the main approach that Stan has here in Expert Lotto with filtering out undesirable number sets Wheel Generator is a very powerful tool in arranging your numbers in the best way.
falcon